Brouhaha? Is that anything like a donnybrook?
I'll also use the "horse" phrase occasionally, but can't say I've ever heard anyone use the "powder my nose" phrase in a non-facetious manner. In our circle of family and friends people usually say, "I need to use the rest room," which is pretty much on-point. Or they'll simply say, "I'll be back," as a way of excusing themselves, and leave to let everyone figure it out on their own.
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